The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging
نویسندگان
چکیده
The most notable obstacle of brain cancer diagnosis is the inability of delivering imaging agents across the blood-brain barrier (BBB). Recently, quantum dots (QDs) has been demonstrated as an ideal image agent for brain imaging due to their ultra-small size for crossing BBB. The plolyamidoamine dendrimers modified CdTe/CdS core/shell near-infrared (NIR) region QDs was successfully synthesized in aqueous solution, and then was characterized by UV-vis absorption, photoluminescence (PL) spectroscopy, dynamic light scattering (DLS), X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM), etc. Our results reveal that the dendrimers modified CdTe/CdS QDs exhibits good water-dispersity and stable NIR fluorescence in various biological environments. In addition, this NIR QDs demonstrates a good biocompatibility and sensitive photoluminescence responses in brain tumor cell imaging. In a word, this type of dendrimers modified NIR CdTe/CdS QDs has huge potential applications in brain imaging.
منابع مشابه
Synthesis and Characterization of Graphene-ZnO Nanocomposite and its Application in Photovoltaic Cells
In this paper, we present a simple method for preparation of graphene-ZnO nanocomposites (G-ZnO). The method is based on thermal treatment of the graphene oxide (GO)/ZnO paste which reduces the graphene oxide into the graphene and leads to the formation of the G-ZnO nanocomposite. The structure, morphology and optical properties of synthesized nanocomposites are characterized with XRD, FESEM, F...
متن کاملSynthesis and Spectral Studies of CdTe–Dendrimer Conjugates
In order to couple high cellular uptake and target specificity of dendrimer molecule with excellent optical properties of semiconductor nanoparticles, the interaction of cysteine-capped CdTe quantum dots with dendrimer was investigated through spectroscopic techniques. NH(2)-terminated dendrimer molecule quenched the photoluminescence of CdTe quantum dots. The binding constants and binding capa...
متن کاملA Simple Image Analysis Method for Determination of Glucose by using Glucose Oxidase CdTe/TGA Quantum Dots
Glucose, as the major energy source in cellular metabolism, plays an important role in the natural growth of cells. Herein, a simple, rapid and low-cost method for the glucose determination by utilizing glucose oxidase and CdTe/thioglycolic acid (TGA) quantum dots (QDs) on a thin layer chromatography (TLC) plate has been described. The detection was based on the combination of the glucose enzym...
متن کاملNear-infrared peptide-coated quantum dots for small animal imaging.
We have synthesized high quality type-II CdTe/CdSe near infrared quantum dots using successive ion layer adsorption and reaction chemistry. Transmission electron microscopy reveals that CdTe/CdSe can be synthesized layer by layer yielding quantum dots of narrow size distribution. Excitation and photoluminescence spectra reveal discrete type-II transitions, which correspond to energy lower that ...
متن کاملحساس سازی همزمان سلولهای خورشیدی نقاط کوانتومی متشکل ازفوتوآند نانوبلوری TiO2 با نانوذرات CdS و PbS و بررسی تأثیر نقاط کوانتومی PbS بر عملکرد سلول خورشیدی
In this research, CdS and PbS quantum dots were applied as the light sensitizers in TiO2 based nanostructured solar cells. The PbS quantum dots could absorb a wide range of the sunlight spectrum on earth due to their low bandgap energy. As a result, the cell sensitization is more effective by application of both CdS and PbS quantum dots sensitizers. The TiO2 nanocrystals were synthesized throug...
متن کامل